AskDefine | Define conceive

Dictionary Definition

conceive

Verb

1 have the idea for; "He conceived of a robot that would help paralyzed patients"; "This library was well conceived" [syn: gestate, conceptualize, conceptualise]
2 judge or regard; look upon; judge; "I think he is very smart"; "I believe her to be very smart"; "I think that he is her boyfriend"; "The racist conceives such people to be inferior" [syn: think, believe, consider]
3 become pregnant; undergo conception; "She cannot conceive"; "My daughter was conceived in Christmas Day"

User Contributed Dictionary

English

Etymology

From the Latin concipere, to take in.

Pronunciation

Verb

  1. To develop an idea.
  2. To understand someone.
  3. To become pregnant.

Translations

To develop an idea
To understand someone
To become pregnant

Extensive Definition

For soil improvement see Fertilization (soil).
Fertilisation (also known as conception, fecundation and syngamy), is fusion of gametes to produce a new organism of the same species. In animals, the process involves a sperm fusing with an ovum, which eventually leads to the development of an embryo. Depending on the animal species, the process can occur within the body of the female in internal fertilisation, or outside in the case of external fertilisation.
The entire process of development of new individuals is called procreation, the act of species reproduction.

Fertilisation in plants

Flowering plants

After the pistil is pollinated, the pollen grain germinates in a response to a sugary fluid secreted by the mature stigma called semen. From each pollen grain, a pollen tube grows out attempting to travel into the ovary by creating a path through the female tissue. The vegetative (or tube) and generative nuclei of the pollen grain pass into its respective pollen tube. The growth of the pollen tube is controlled by the vegetative (or tube) nucleus. Hydrolytic enzymes are secreted by the pollen tube to digest the female tissue (stigma and style) as the pollen tube grows. During pollen tube growth toward the ovary, the generative nucleus divides to produce two separate sperm nuclei - a growing pollen tube therefore contains three separate nuclei. The pollen tube does not directly reach the ovary in a straight line. It travels near the skin of the style and curls to the bottom of the ovary, then near the receptacle, it breaks through the ovule through the micropyle (an opening in the ovule wall) and reaches the ovum (or egg cell) to fertilise it. This is the point when fertilisation actually occurs. Note that pollination and fertilisation are two separate processes. After being fertilised, the ovary starts to swell and will develop a fruit. With multi-seeded fruits, multiple grains of pollen are necessary for syngamy with each ovule.
The process is easy to visualize if one looks at maize silk, which is the female flower of corn. Pollen from the tassel (the male flower) falls on the sticky external portion of the silk, and then pollen tubes grow down the silk to the attached ovule. The dried silk remains inside the husk of the ear as the seeds mature; if one carefully removes the husk, the floral structures may be seen. In many plants, the development of the flesh of the fruit is proportional to the percentage of fertilised ovules. For example, with watermelon, about a thousand grains of pollen must be delivered and spread evenly on the three lobes of the stigma to make a normal sized and shaped fruit.

Double fertilisation anchor double fertilisation

Double fertilisation is the process in angiosperms (flowering plants) during reproduction, in which two sperm nuclei from each pollen tube fertilise two cells in an ovary. The pollen grain adheres to the stigma of the carpel (female reproductive structure) and grows a pollen tube that penetrates the ovum through a tiny pore called a micropyle. Two sperm cells (derived from the generative nucleus) are released into the ovary through this tube. One of the two sperm cells fertilises the egg cell (at the end of the ovary), forming a diploid (2n) zygote. The other sperm cell fuses with two haploid polar nuclei (contained in the central cell) in the centre of the embryo sac (or ovule). The resulting cell is triploid (3n). This triploid cell divides through mitosis and forms the endosperm, a nutrient-rich tissue, inside the seed.
The two central cell maternal nuclei (polar nuclei) that contribute to the endosperm arise by mitosis from a single meiotic product. Therefore, maternal contribution to the genetic constitution of the triploid endosperm is different from that of the embryo.
Recently, research has shown that in one primitive group of flowering plants, the water lilies, Nuphar, the endosperm is diploid, resulting from the fusion of a pollen nucleus with one, rather than two, maternal nuclei.
In gymnosperms, such as conifers, the food storage tissue is part of the female gametophyte only, a haploid (1n) tissue, so there is no double fertilisation.

Fertilisation in animals

The mechanics behind fertilisation has been studied extensively in sea urchins and mice. This research addresses the question of how the sperm and the appropriate egg find each other and the question of how only one sperm gets into the egg and delivers its contents. There are three steps to fertilisation that insure species-specificity:
  1. Chemotaxis
  2. Sperm activation/acrosomal reaction
  3. Sperm/egg adhesion.

Sea urchins

Chemotaxis was discovered as the method by which sperm find the eggs. This chemotaxis is an example of a ligand/receptor interaction. Resact is a 14 amino acid peptide purified from the jelly coat of A. punctulata that attracts the migration of sperm.
After finding the egg, the sperm gets through the jelly coat through a process called sperm activation. In another ligand/receptor interaction, an oligosaccharide component of the egg binds and activates a receptor on the sperm and causes the acrosomal reaction. The acrosomal vesicles of the sperm fuse with the plasma membrane and are released. In this process, molecules bound to the acrosomal vesicle membrane, such as bindin, are exposed on the surface of the sperm. These contents digest the jelly coat and eventually the vitelline membrane. In addition to the release of acrosomal vesicles, there is explosive polymerization of actin to form a thin spike at the head of the sperm called the acrosomal process.
The sperm binds to the egg through another ligand reaction between receptors on the vitelline membrane. The sperm surface protein bindin, binds to a receptor on the vitelline membrane identified as ERB1.
Fusion of the plasma membranes of the sperm and egg are likely mediated by bindin. At the site of contact, fusion causes the formation of a fertilisation cone.

Mammals

All mammals rely on internal fertilisation through copulation. To deliver the sperm to the female, the male inserts his sexual organ, the penis, into the opening of the vagina, the passage into the female's other sexual organs. Once the male ejaculates, a large number of sperm cells swim from the upper vagina through the cervix and across the length of the uterus toward the ovum—a considerable distance compared to the size of the sperm cell. The capacitated spermatozoon and the oocyte meet and interact in the ampulla of the fallopian tube. It is probable that chemotaxis is involved in directing the sperm to the egg, but the mechanism has yet to be worked out.
After finding the egg, the sperm binds to the zona pellucida. In contrast to sea urchins, the sperm binds to the egg before the acrosmal reaction. The zona pellucida is a thick layer of extracellular matrix that surrounds the egg and is similar to the role of the vitelline membrane in sea urchins. A glycoprotein in the zona pellucida, ZP3 was discovered to be responsible for egg/sperm adhesion in mice. The receptor galactosyltransferase (GalT) binds to the N-acetylglucosamine residues on the ZP3 and is important for binding to sperm and activating the acrosome reaction. ZP3 is sufficient for sperm/egg binding but not necessary. There are two additional sperm receptors: a 250kD protein that binds to an oviduct secreted protein and SED1 which binds independently to the zona. After the acrosome reaction, it is believed that the sperm remains bound to the zona pellucida through exposed ZP2 receptors. These receptors are unknown in mice but have been identified in guinea pigs.
In mammals, binding of the spermatozoon to the GalT initiates the acrosome reaction. This process releases the enzyme hyaluronidase, which digests the matrix of hyaluronic acid in the vestments surrounding the oocyte. Fusion between the sperm and oocyte plasma membranes follows, allowing the entry of the sperm nucleus, mitochondria, centriole and flagellum into the oocyte. The fusion is likely mediated by the protein CD9 in mice (the binding homolog). Once the ovum fuses with a single sperm cell, its cell membrane changes, preventing fusion with other sperm (see Egg activation).
This process ultimately leads to the formation of a diploid cell called a zygote. The zygote begins to divide and form a blastocyst and when it reaches the uterus, it performs implantation in the endometrium. At this point the female is said to be pregnant. If the embryo emplants in any tissue other than the uterine wall, an ectopic pregnancy results, which can be fatal to the mother.
In some animals (e.g. rabbits) the act of coitus induces ovulation by stimulating release of the pituitary hormone gonadotropin. This greatly increases the probability that coitus will result in pregnancy.

Humans

The term conception commonly refers to fertilisation, but is sometimes defined as implantation or even "the point at which human life begins", and is thus a subject of semantic arguments about the beginning of pregnancy, within the abortion debate.
Gastrulation is the point in development when the implanted blastocyst develops three germ layers, the endoderm, the exoderm and the mesoderm. It is at this point that the genetic code of the father becomes fully involved in the development of the embryo. Until this point in development, twinning is possible. Additionally, interspecies hybrids survive only until gastrulation, and have no chance of development afterward. However this stance is not entirely warranted since human developmental biology literature refers to the "conceptus" and the medical literature refers to the "products of conception" as the post-implantation embryo and its surrounding membranes. The term "conception" is not usually used in scientific literature because of its variable definition and connotation.

Fertilisation and genetic recombination

Meiosis results in a random segregation of the genes contributed from each parent. Each parent organism generally has the same genetic make-up, but differs for a fraction of their genes. Therefore, each gamete produced by a person will be genetically different from the others from that person, as well as from the gametes produced by another person. When gametes first fuse at fertilisation, the chromosomes donated by the parents are combined, and, in humans, this means that (2²²)² (17,592,186,044,416 possible zygotes), chromosomally different zygotes are possible for the non-sex chromosomes, even assuming no chromosomal crossover. If crossover occurs once, then on average (4²²)² (309,485,009,821,274,699,980,603,392) genetically different zygotes are possible for every couple, not considering that crossover events can take place at most points along each chromosome. The X and Y chromosomes do not undergo crossover events, so are excluded from the calculation. Note that the mitochondrial DNA is only inherited from from the maternal parent.

Parthenogenesis

Another method of fertilisation occurs among animals that normally reproduce sexually, through parthenogenesis: when the gamete of a female is not fertilised by a male, yet produces viable and unique offspring that are not clones. Only DNA from the mother is inherited, but it is not identical to her. Normal eggs of the mother become fertilised, without sperm, and development proceeds normally. This occurs naturally in several species and may be induced in others through a chemical or electrical stimulus. In 2004, Japanese researchers led by Tomohiro Kono succeeded after 457 attempts to merge the ova of two mice, the result of which developed normally into a mouse. This was achieved by blocking certain proteins that would normally prevent the possibility.

Notes and references

conceive in Bengali: নিষেকক্রিয়া
conceive in Breton: Speriañ
conceive in Bulgarian: Зачеване
conceive in Catalan: Fecundació
conceive in Czech: Oplodnění
conceive in Danish: Befrugtning
conceive in German: Befruchtung
conceive in Spanish: Fecundación
conceive in French: Fécondation
conceive in Croatian: Oplodnja
conceive in Indonesian: Pembuahan
conceive in Italian: Fecondazione
conceive in Hebrew: הפריה
conceive in Lithuanian: Apvaisinimas
conceive in Macedonian: Оплодување
conceive in Dutch: Bevruchting
conceive in Japanese: 受精
conceive in Norwegian: Befruktning
conceive in Polish: Zapłodnienie
conceive in Portuguese: Fecundação
conceive in Romanian: Fecundaţie
conceive in Quechua: Yumay
conceive in Russian: Половой процесс
conceive in Simple English: Fertilization
conceive in Slovak: Oplodnenie
conceive in Serbian: Оплођење
conceive in Sundanese: Fértilisasi
conceive in Finnish: Hedelmöitys
conceive in Swedish: Befruktning
conceive in Turkish: Döllenme
conceive in Ukrainian: Запліднення
conceive in Chinese: 受精

Synonyms, Antonyms and Related Words

absorb, accept, account as, animate, appreciate, apprehend, assimilate, assume, author, be acquainted with, be afraid, be apprised of, be aware of, be cognizant of, be conscious of, be conversant with, be informed, be with one, bear, beget, believe, breathe life into, breed, bring about, bring forth, bring into being, bring into existence, bring to effect, bring to life, bring to pass, call into being, call into existence, catch, catch on, cause, cerebrate, cogitate, cognize, coin, come with child, compass, comprehend, conceit, conceptualize, conclude, concoct, conjure up, consider, contrive, cook up, couch, couch in terms, create, daresay, deduce, deem, design, develop, devise, dig, digest, discern, discover, divine, do, dream, dream up, effect, effectuate, embody in words, endow with life, energize, engender, entertain ideas, envisage, envision, establish, esteem, estimate, evolve, excogitate, exercise the mind, expect, experience imaginatively, express, fabricate, fancy, fantasize, father, fathom, feature, feel, fictionalize, follow, form, form ideas, formularize, formulate, found, frame, gather, generate, gestate, get, get hold of, get the drift, get the idea, get the picture, give being to, give birth, give birth to, give expression to, give life to, give occasion to, give origin to, give rise to, give words to, grant, grasp, guess, hatch, have, have a hunch, have an idea, have an impression, have an inkling, have information about, have it taped, have knowledge of, have the idea, heed, hold, hold as, hypothesize, ideate, image, imagine, improvise, inaugurate, infer, inspirit, institute, intellectualize, invent, judge, ken, know, learn, let, let be, look upon as, maintain, make, make do with, make out, make up, mark, master, mature, meditate, mint, mold, note, notice, observe, occasion, opine, originate, paragraph, perceive, phrase, plan, plot, ponder, posit, possess, postulate, prefigure, prehend, present, presume, presuppose, presurmise, procreate, produce, provisionally accept, put, put in words, quicken, read, realize, reason, reckon, recognize, regard, remark, repute, rhetorize, ruminate, savvy, say, see, seize, seize the meaning, sense, set afloat, set down as, set on foot, set out, set up, shape, sire, spawn, speculate, state, strike out, style, suggest, superfetate, suppose, surmise, suspect, take, take for, take for granted, take in, take it, take to be, think, think out, think up, trow, twig, understand, view as, vision, visualize, vitalize, vivify, ween, word, work, wot, wot of
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